What type of stem cells is used in the methodology?

The MIBRAR methodology uses autologous mesenchymal stem cells obtained from the patient's own adipose tissue using certified equipment. The use of lipogenic fraction ALF® eliminates rejection and allergic reactions. These cells are able to differentiate into various types of musculoskeletal tissues and actively participate in their regeneration.

How is regeneration achieved?

Regeneration is achieved through the administration of autologous concentrates ALF® and AHF® containing stem cells and growth factors obtained from the patient's adipose tissue and blood. Unique MIBRAR® micro-invasive instruments are used, allowing minimally traumatic delivery of the concentrate to the damaged area and activation of natural tissue restoration processes.

How do Mibrar® regenerative concentrates differ from PRP and stromal vascular fraction?

Mibrar® regenerative concentrates are used fresh, without impurities and preservation. The regeneration process occurs exclusively in the body (in vivo), not outside it (in vitro). Certified class 2A equipment is used to obtain them. Unlike PRP or unpurified SVF, Mibrar® concentrates provide higher efficiency and safety.

How are Mibrar® regenerative concentrates prepared?

ALF® and AHF® concentrates are prepared according to strict criteria: exclusively autologous, without impurities; separation is performed mechanically on MIBRAR® equipment (Medifuge MF 200 and disposable sets). The use of laboratory centrifuges or chemical methods is strictly prohibited. Concentrates are used fresh, without freezing or preservation.

What is micro-invasive intervention?

Micro-invasive intervention is a procedure through a minimal puncture using micro-instruments, endoscopes and navigation devices. This method minimizes tissue trauma, accelerates recovery and eliminates the need for large incisions. Within MIBRAR technology, a technique of applying fresh injuries is used to activate regeneration.

Can the MIBRAR methodology be used in elderly patients and those with chronic diseases?

Yes, the MIBRAR® methodology is safe for patients of any age, including the elderly. The patient's own tissues and micro-invasive techniques are used, making the procedure acceptable even with chronic diseases and contraindications to classical operations.

Are there risks or complications when using the MIBRAR® methodology?

Risks are minimal as the patient's own cells are used. Before the procedure, a complete examination is performed, the patient is informed and signs consent for the intervention. All safety protocols are followed.

Can bone marrow cells be used to treat joints?

Bone marrow cells are not used in MIBRAR® technology as they contain only multipotent cells, less versatile compared to pluripotent adipose tissue cells. In addition, bone marrow collection requires invasive intervention under anesthesia and carries a risk of complications.

What is the success rate of MIBRAR® treatment?

Based on over 25,000 procedures at Munich clinics: 20% improvement from day one, 35% by week 2, 25% by week 4, 15% by week 6, up to 85% total improvement by weeks 8–16. MIBRAR® covers up to 95% of diagnostic and therapeutic procedures in orthopedics and neurosurgery.

Regenerative Medicine MIBRAR®

Q: What is the RRBSW method and how does it restore intervertebral discs?

RRBSW (Regeneration und Rekonstruktion der Bandscheiben und Segmente der Wirbelsäule) is a specialized method within MIBRAR® technology for restoring intervertebral discs through intradiscal transplantation of autologous regenerative concentrate ARK®. The method enables treatment of disc herniations, degenerations, stenosis and spondylolisthesis. Follow-up scans 3–18 months after the procedure document progressive restoration of disc structure.

More about MIBRAR®:

MIBRAR® (Mikro-Invasive Biologische Regenerative Autologe Rekonstruktion) is a unique micro-invasive biological regenerative autologous reconstruction technology developed in Munich, Germany. The method is used in orthopedics and neurosurgery, covering up to 95% of diagnostic and therapeutic procedures in these fields. MIBRAR® helps patients recover without joint replacement, extensive spinal surgery, anesthesia, or incisions. Treatment does not require hospitalization and is suitable for patients of any age.

The fundamental principle of MIBRAR® — «Kein Schnitt, nur ein Stich!» (German for «No cut, only a puncture!»). A surgical incision creates a competing wound to which stem cells and growth factors migrate, diverting them from the actual pathology. The micro-invasive puncture (0.3–1.5 mm) directs all regenerative energy of ARK® concentrates precisely to the affected area.

25,000+

Successful MIBRAR® procedures at Munich clinics

95%

Coverage of orthopedic and neurosurgical procedures

0.3–1.5 mm

Puncture size — no incisions, no anesthesia, no hospitalization

Munich

Central MIBRAR® clinic — Germany, Prof. Babayan

About the Technology

Professor Arsen Babayan — Professor
Arsen Babayan

MIBRAR® was developed by Professor Babayan to help patients with severe musculoskeletal injuries. The method is based on the natural ability of human body tissues to regenerate.

MIBRAR involves the use of autologous concentrates that initiate the process of reconstruction and restoration of structures damaged by injuries and diseases.

MIBRAR® technology is used for treating:

spine — for osteoarthritis, osteochondrosis, intervertebral hernias, protrusions, stenoses;
knee joint — for cruciate ligament tears, arthritis, synovitis;
hand — for deforming osteoarthritis;
hip joint — for coxarthrosis, necrosis;
shoulder and elbow — for bursitis, tendinitis.

MIBRAR® technology is also used for other musculoskeletal pathologies.

Treatment provides the opportunity to:

forget about pain and discomfort;
prevent disability, improve quality of life;
restore structures damaged due to injury or degenerative processes.

This unique procedure does not require lengthy recovery, it is suitable for people of any age.

MIBRAR Clinics and Centers

The MIBRAR® methodology is actively being implemented in clinical practice and is now available in the following countries:

Germany – Munich
Russia – Moscow, Yekaterinburg
Armenia – Yerevan
Vietnam – Hanoi, Ho Chi Minh City
France – Antibes (in preparation)
Monaco – Monaco (in preparation)
Kyrgyzstan – Bishkek (in preparation)

All clinics and regional centers operate under the coordination of the MIBRAR® central office, complying with the legal requirements and medical standards of their respective countries.

Contact number for international inquiries:
+49 176 17917001
Medical manager:
info@doktormunchen.de

Certificate — "Doktor München" company is the only official representative of Professor Babayan in CIS countries and is authorized to provide complete information, consultations and treatment organization using MIBRAR® technology

Unique Approach

The MIBRAR methodology has a number of unique advantages that favorably distinguish it from traditional surgical interventions and joint replacement:

No incisions: procedures are performed without major surgical incisions, which reduces pain and risk of infection.
No prostheses or implants: treatment is aimed at restoring the body's own tissues, eliminating the need for artificial materials.
Minimal risks: the absence of general anesthesia and minimal invasiveness reduce the likelihood of complications.
Fast recovery: patients return to normal life in the shortest possible time, as there is no need for long rehabilitation.

Brief Comparison with Traditional Methods

Parameter	MIBRAR	Traditional Surgery
Surgical incisions	No	Yes
Use of prostheses	No	Yes
Need for anesthesia	No	Yes
Risk of complications	Minimal	Medium or high
Rehabilitation period	Short (1-2 days)	Long (weeks or months)

MIBRAR® Clinical Cases

Explore real treatment results of patients using MIBRAR® technology. Each case is documented with MRI scans before and after treatment: knee arthrosis, disc herniations, spinal stenosis, scoliosis, meniscus tear and other pathologies.

View cases →

700+

documented
clinical cases

MIBRAR® Technology Criteria and Differences from Other Musculoskeletal Treatment Methods Without Classic Open or Endoscopic Surgeries and Joint Replacement

The therapeutic effect of MIBRAR® interventions, ensuring regenerative reconstruction of affected structures of the human body with restoration of their functions, can only be achieved through strict adherence to principles in all necessary aspects provided by MIBRAR® technology protocols: clinical, surgical and biological. Deviation from the principles and protocols of MIBRAR® technology makes achieving the intended regenerative reconstruction effect impossible.

1. Clinical Criteria	2. Surgical Criteria	3. Biological Criteria
a) Diagnostics: classical and innovative diagnostics using MIBRAR® with correction of gross diagnostic errors leading to additional irreparable health damage. b) Indications: determining the correct intervention method of the MIBRAR® system. c) MIBRAR® Intervention: acceptability of intervention considering risks and effectiveness. d) Postoperative patient management: consultation on the postoperative regeneration process and recommendations for lifestyle and physiotherapy. e) Maintaining protocols for examinations and operations using MIBRAR® technology.	a) MIBRAR® surgical principles. b) MIBRAR® intervention methods. c) Surgical skills of MPSR® and MIPKAT® techniques developed in MIBRAR® technology. d) Application of patented MIBRAR® instrumentation. e) Application of MIBRAR® technology equipment.	a) Modern scientific knowledge on the biological process of regeneration. b) Criteria for acceptable ARK® separation methods. c) Action and Application of ARK® in various pathologies. d) Modern acceptable and effective equipment. e) Skills in working with equipment, sets and instrumentation of ARK® separation systems using MIBRAR® technology.

MIBRAR® Features

Camera size 1 x 1.4 x 1 mm

Micro-invasive Approach

Micro-invasive surgery does not require large incisions. During the procedure, the surgeon makes a small puncture and introduces endoscopic instruments through it — micro-dimensional endoscope, epiduroscope, arthroscope, and uses the Cyber Navi Hand navigation system. All endoscopic equipment and computer programs used during the operation were specially created by German engineers.

Biological Processes

Due to the absence of large incisions, the patient does not need to stay in the clinic. Within a few hours they can go home. Another advantage of minimally invasive intervention is the ability to avoid general anesthesia. Tissues at the puncture site recover quickly, the rehabilitation period is reduced to a minimum. The patient can move in the usual manner after the operation.

Reconstructive Effect

The reconstructive effect of the procedure is achieved through implantation of regenerative concentrates prepared from the patient's venous blood and adipose tissue. The concentrates contain stem cells, growth factors, and cytokines. These components trigger natural restoration and reconstruction processes of damaged structures. Cartilage, intervertebral discs, ligaments, and muscles are renewed. The patient is freed from pain, and the spine and joints begin to function normally again.

In many cases, MIBRAR eliminates the need for traditional extensive surgeries.

Camera size 1 x 1.4 x 1 mm

Micro-invasive Approach

Biological Processes

Reconstructive Effect

In many cases, MIBRAR eliminates the need for traditional extensive surgeries.

Concentrates

MIBRAR technology involves the use of natural concentrates obtained from the patient's own tissues. No synthetic substances are used to obtain them.

Two types of autologous concentrates are used during the operation:

CGF plasma. Contains growth factors, anti-inflammatory factors, platelets. The patient's venous blood is used to obtain the concentrate. CGF plasma activates the transmission of signals about the presence of damage in tissues and triggers the production of growth factors, cytokines in the problem area, provides damaged tissues with new stem cells.
LIPOGEMS — concentrate from the patient's adipose tissue (obtained by liposuction) with a high concentration of lipogenic and regenerative substances. Mesenchymal stem cells contained in the concentrate transform into cells of the damaged tissue and restore it.

Lipogems technology received a patent in 2010 and has been used worldwide since 2013 for the treatment of arthrosis, osteoarthritis, damage to intervertebral and joint ligaments, cartilage, muscles, tendons. This absolutely safe procedure was included in the list of the best sports medical technologies in the world in 2016 (Sports Medicine Technology Awards).

Only freshly prepared concentrates are used for MIBRAR operations. They are prepared on certified equipment with a special mode for destroying cancer cells.

Treatment Stages

MIBRAR — is a micro-invasive procedure, highly precise and complex. It is performed using a specially developed Cyber-Navi-Hand targeting navigation device.

Preparation for surgery includes:

Entering the patient's 3D X-ray images into a special computer program, analyzing them, selecting instrumentation to provide access to the problem area. The doctor draws up an operation plan.
Obtaining autologous concentrate from venous blood and adipose tissue. Venous blood is taken with syringes and placed in labeled test tubes. It is subjected to centrifugation with temperature, acceleration and deceleration power control, cancer cells are separated and destroyed. Adipose tissue is prepared in a special system.

Planning and operation control:

The patient is on the operating table, the C-arm X-ray unit takes a series of images. In the Cyber-Navi-Hand program, the obtained images are combined with those taken earlier, the virtual operation plan is adapted to the patient's position, information is processed. The Cyber Navi Hand tube is positioned above the operated surface. The system controls manipulations (angle accuracy up to 1 degree, depth up to 1 mm), this allows avoiding damage to healthy tissues.

Concentrate administration is performed using high-resolution equipment — micro-dimensional endoscopes, epiduroscopes, arthroscopes. The doctor does not make incisions, so there are no scars or marks left on the body. The size of the puncture through which endoscopic equipment is introduced is no larger than from a regular injection. Within a few hours, the mark on the body becomes invisible.
After the concentrates are administered, their components are directed to the damaged areas "marked" by the surgeon. The recovery process begins.

In patients operated on using MIBRAR technology, severe pain subsides within a few days. Full restoration of damaged structures requires 8 to 16 weeks.

The technology makes it possible to treat several damaged areas of the musculoskeletal system at once. The result of the operation can be assessed after 2-4 months. For control, an examination is performed, including ultrasound scanning, radiography, computed tomography or magnetic resonance imaging.

Patient Reviews

View more reviews

RRBSW Method — Intervertebral Disc Regeneration

RRBSW (Regeneration und Rekonstruktion der Bandscheiben und Segmente der Wirbelsäule) is a specialized method within the MIBRAR® technology aimed at restoring the height, volume and shape of intervertebral discs through intradiscal transplantation of autologous regenerative concentrate ARK®.

The RRBSW method enables treatment without extensive surgical intervention:

Disc herniations (cervical, thoracic and lumbar spine);
Disc degeneration and osteochondrosis;
Spinal canal and foraminal stenosis;
Spondylolisthesis and segment instability;
Post-operative recurrences and syndromes.

Follow-up MRI and CT scans 3–18 months after the RRBSW procedure document progressive restoration of disc structure: height increase, disappearance of herniation sequester, decompression of nerve roots. Learn more about the RRBSW method and MIBRAR® instruments →

Advantages of MIBRAR® Method

MIBRAR® technology offers a number of unique advantages, confirmed by over 25,000 procedures at Munich clinics (Germany):

No anesthesia — the procedure is performed under local anesthesia, eliminating the risks of general anesthesia.
No incisions — access through micro-puncture 0.3–1.5 mm. No scars on the skin.
No bleeding risk — micro-invasiveness eliminates vessel damage.
No medications — only the patient's own biomaterials are used (blood and adipose tissue).
No prostheses or implants — restoration of own tissue instead of replacement with artificial materials.
No cortisone — autologous ARK® concentrates have a natural anti-inflammatory effect.
No side effects — autologous materials do not cause rejection or allergies.
No contraindications — suitable for chronic diseases, allergies and anesthesia intolerance.
No hospitalization — outpatient procedure, the patient goes home the same day.
No rehabilitation — no crutches, braces or assistive devices required.
No age restrictions — regeneration occurs at any age.
Simultaneous treatment — ability to treat multiple joints and structures in one procedure.

Treatment results are confirmed by imaging (MRI, CT, X-ray, sonography) 8–16 weeks after the procedure. Compare MIBRAR® with other methods →

All equipment and instrumentation described above, developed by Prof. Babayan, are protected by patent.
Prof. Babayan holds copyright on MIBRAR® technology